ELEPHANT-1

ELEPHANT-1

Titel: Impact of parathyroidectomy timing (pre- or post-transplantation) due to secondary hyperparathyroidism on kidney graft survival.

Leading center: UMCG,  R.A. Pol

Doel: The aim of this study is to assess the effect of the timing of PTX on graft survival.

Hypothese: We hypothesize that the PTX after the most recent NTX has a better effect on graft survival than performing the PTX before the NTX. Additionally performing PTX as treatment for persistent SHPT is more beneficial for long-term graft survival than conservative treatment. As a result a recommendation on treatment of 2HPT in clinical practice will be voiced.

Primary outcomes: The primary outcome of our analysis is a death-censored investigation of deteriorating graft function using eGFR at 3-years post transplantation. The highest eGFR post NTX will be recorded and a 50% loss after 5 years follow up will be regarded as endpoint.

Secondary outcomes: Secondary outcomes will be: serum calcium, PTH, annual change in eGFR (ml/min/1.73 m2/yr), and mortality.

Design: Multicenter case-matched retrospective analysis